PREDICT Latent TB Study

The UK Prognostic Study of the Interferon Gamma Release Assay for Tuberculosis (PREDICT)

Welcome to the website for the PREDICT study, which will look at the tests that are available for diagnosing people with tuberculosis, TB. This study is funded by the NIHR HTA Programme and coordinated by Public Health England.  We are working in NHS sites, clinics, GP surgeries and community settings to investigate prognostic value of tests for latent tuberculosis infection.

Why are we doing the study?

TB is a disease which can take a long time to develop after a person is infected with the bacteria. The time between infection and becoming ill with symptoms of TB is called the latent period. During the latent period, some people manage to beat the infection and do not go on to have symptoms, but other people do go on to become ill. The tests that we have at the moment are not able to tell us who will become ill and who won’t. In this study we will be looking at some new tests that may help to do this so that we don’t treat people who will stay well, especially because some of the TB treatments have some side effects.

Who can take part and how do I find out more?

We will be recruiting 10,000 people who have been in contact with someone who has active TB, or people who have recently moved to the UK (in the last five years) living in London. Taking part in the study will involve a blood test and a few phone calls or allowing us to look at your hospital or GP notes so that we can see how you are over the next few years. The full information about the study is in the study leaflet and flowcharts which you can download. These will help you decide whether you would like to take part. If you are interested, the next step is to speak to a study nurse at the centre nearest where you live to make an appointment. If you would rather we get the nurse to phone you, please email us your details (name, phone number and location i.e. which area of London you live in).

Our academic partners include

University College London

Imperial College

University of Birmingham

Queen Mary University of London

Brunel University